There has been a lot over the years. I'll name a few highlights.
Angel Cop (but thats unintentional)
B Gata H Kei
Bokusatsu Tenshi Dokuro-chan
Buttobi!! CPU (on dvd as I dream on Mimi)
Hanappe Bazooka
Iketeru Futari
Kekkou Kamen
Mangaka-san to Assistant-san to The Animation (I think it was ep 11 that had me in stitches)
Mitsudomoe
Mitsudomoe Zouryouchuu!
Oruchuban Ebichu
Seitokai Yakuindomo (I REAALLY need to see the 2nd series)
Watamote
Since it first aired, I've watched Shomin Sample (Ore ga Ojou-sama Gakkou ni Shomin Sample Toshite Gets-sareta Ken) several times, and it always makes me smile.
Gintama is by far the most hilarious anime series with massive "Adult Jokes".
Then comes mitsudomoe and its second season that also deals with some "Adult Jokes".
devil is a part-timer and Cuticle Tantei Inaba that doesn't deal with "Adult Jokes" as far as I watched.
so for me the comedic aspects of anime always depends on the quantity of "Adult Jokes".