Whenever I start a new game, I usually spend quite a bit of time adjusting the settings.
First is the text speed. I always set it to instant display because I need to search for the game's text hook. If the text appears too slowly, the hooking software sometimes can't catch it properly. Another reason is that the default text speed in many games feels really slow, and usually the translation tool only starts translating after the text fully appears. So it gets pretty annoying when some games still can't display text instantly even at the maximum speed setting.
Second is the skip speed. I always set it to the fastest possible setting. Nobody skips while actually reading the text, people skip because they want to reach the next choice as quickly as possible.
Third is switching to windowed mode. I rarely play in fullscreen because I often need to check walkthroughs, look up information, and do other things while playing.
Fourth is the BGM settings. I usually adjust this after playing for a while. Depending on the game, if the soundtrack is really good but too quiet, I'll increase the volume. But if the BGM isn't very good or doesn't fit the atmosphere, I'll lower it or even mute it completely.
Fifth is character voices. I usually raise the LI voices to the maximum volume while leaving side characters at the default level. And if the game has a voiced protagonist, I normally lower the protagonist's voice to around 25% or mute it entirely.
Sixth is the 'continue voice after advancing text' feature. Since I read pretty fast, it feels strange when the voice suddenly gets cut off every time I move to the next line. So I really like enabling this feature because I can continue reading new lines while still hearing the unfinished voice clip. It's a really nice feature, although not many games include it.
And lastly, the game font. Some games let us choose different fonts, and I usually prefer fonts that are easy to read and have strong contrast with the background.