I would try completely uninstalling the game, then using CCleaner or something of its kind to repair any registery keys left behind by Honey Select, then restarting your PC and doing a complete fresh install of Honey Select then try playing the game without changing settings to see if it will...
Recently played through DragonBall Z Sagas for GameCube / PlayStation 2 and it got me in the mood for some more action, so I'm currently playing DragonBall Xenoverse, loving the action and combat improvements so far that this game has improved on since the last DragonBall games I've played (...