You extract everything.
Afterwards just download this, extract & run it (imgdriveportable_x64) and install driver
https://download.yubsoft.com/imgdriveportable_1.9.9.zip

Then drag and drop Natural_Another_One_Disc1.cue onto the interface and
double click it from your This PC folder (where also your harddrives are being shown with drive letters).
Follow installation.

At last you go to the folder you installed the game to and run the exe file of the game.
If it shows black screen just press Shift button on keyboard and you can play.

And if you get this error pop up:

After install eject Natural_Another_One_Disc1.cue from ImgDrive Portable by right clicking in the interface on it and select first option.
Then drag and drop Natural_Another_One_Disc2.cue inside so its on the same drive letter and game should run fine when starting the exe in game folder.