1.月に寄りそう乙女の作法 : It says System Error, code 122.

2.すてぃ～るMyはぁと: This error says that the disc in your drive is not a valid one. To install this game, follow the steps below:
i) Run the file smh_keygen_install.exe(KEEP IT RUNNING UNTIL YOU FINISH YOUR INSTALLATION).
ii) Run the game installer.
iii) Input serial.
iv) Install the game.

To play the game, you need to start it using the 'Use NTLEA to change game locale' option in Visual Novel Reader or standalone NTLEA.

Sorry, I was careless and made a mistake with #1. It's error 122 (NOT 112 as stated in my first reply).

The name length of the directory you're installing from might be too long. Try putting your ISO files tsukiniyorisou_fe.iso and tsukiniyorisou_fe.mds in folders with shorter names, for example: C:\Downloads\Tsuki\

If that doesn't work, I can't help you any further because it's out of my league.

Similar thing happens only with: 月に寄りそう乙女の作法2.1 ''Espar'' is different game by same publisher.
I haven't gotten any standard warning messages, the game window closes during it blinks the logo of publisher.
Maybe it's different game in this case, but others in series tend to work properly on windows 8,1.
Tsuki 2.2 seems to work without Japanese local settings. I did examine something. Not sure if it helps.
Engine_message.u: (translated from Japanese) Something got deleted. Game files suggest using a CD disc on drive.
''// filepack
filepack_initializeerror = Failed to read file pack.
filepack_keyerror = The keys in the package data do not match.
package_cd_fullloaderror = Failed to read package data on DVD.
package_hdd_fullloaderror = Failed to read package data on HDD.
filebroken_error = Corrupt file detected. %%% nfile:% s

// system
mmx_nosupport = Requires a CPU with MMX function.
key_error = License key missing or invalid.
appsetup_error = Insufficient configuration file required to start the engine.
dll_systeminfo_error = Failed to read systeminfo (dll).
dll_oggvorbis_error = Failed to read oggvorbis (dll).
dll_theora_error = Failed to read oggtheora (dll).
engine_setuperror = Failed to initialize the engine.
key_date = A time limited key file can not be used.''

I have a simple rule, if game doesn't work with ISO-file mounter, kDays or AlphaROM build20121001, it's not worth touching.
If I was tech expert I would help.